Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. Hydroquinone is 1,4-benzenediol. Eng. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. Ferulic acid 0.5% 0.15g. Hydroquinone | C6H4(OH)2 or C6H6O2 | CID 785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Antioxidants, preferably sulfites, including but not limited to sulfites, bisulfites, metabisulfites, their salts, and their derivatives, most preferably sodium metabisulfite, have been used to stabilize certain compositions, which have included hydroquinone. This saturated dicarboxylic acid exists as a white powder. Heat Mass Transf. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. Free format text: The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. Formula of hydroquinone is . You can expect to hear back from a ChemPoint product specialist within 1 business hour. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Azelaic acid - Wikipedia Hydroquinone skin cream, gel, emulsion, lotion, or solution Hydroquinone is combustible when preheated. Polysorbate 20 0.5% 0.15g. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. The experimental solubility data was well-correlated with the data, calculated by . 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. This study was funded by Ministre de l'Enseignement Suprieur et de la Recherche Scientifique. Some documentation and label information may refer to the legacy brand. Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. PubMedGoogle Scholar. 0000002379 00000 n Substituted derivatives of this parent compound are also referred to as hydroquinones. Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. PDF HYDROQUINONE - Centers for Disease Control and Prevention Also in this embodiment is a cationic salt of acidic ascorbyl esters, which further helps to maintain the acceptable color desired in the hydroquinone composition. 20grams ofhydroquinonein 20oz is liquid is 10%. Determination and Correlation of Solubilities of Benzoic Acid Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Hydroquinone, 99.5%, Thermo Scientific Chemicals The solubility was increased by addition of ethanol, reached a maximum . Solubility of Hydroquinone in Different Solvents from 276.65 K to 0000005757 00000 n Environ. Toughness of the polymer increases due to the presence of flexible units in the backbone such as long chain diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol) or long chain saturated acids (e.g., adipic . Consistent with a condensation reaction, water was determined to be the primary byproduct. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. 388, 7381 (2010), H. Li, G. Hu, F. Guo, L. Zhao, J. Zhu, Y. Zhang, Can. Hydroquinone is combustible when preheated. 12.4. . Hydroquinone - an overview | ScienceDirect Topics 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. N')].uJr Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. Lastly, I'd like to add benzoic acid for preservation purposes. In 1-octanol, the decreasing order of the solubility of these compounds is as follows: resorcinol>benzoic acid>salicylic acid>hydroquinone. This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. Solubility of Hydroquinone. The present invention combats this problem, with hydroquinone compositions in the neutral pH range, preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. If you are already a ChemPoint customer then sign up for access to our online ordering website. Variations in pH have proven to result in excessive discoloration ranging from brownish to black. Airborne hydroquinone may be oxidized to quinone at ordinary . Discoloration of hydroquinone compositions may be accelerated by repeated exposure to oxygen or exposing the compositions to high temperatures, which may be found inside a car or delivery vehicle on a hot sunny day. These reactions release free oxygen and generate enough heat to bring the mixture to the boiling point and vaporize about a fifth of it, producing a hot spray from the beetle's abdomen. The obtained results show that the . Protected retinoid, with its skin benefit capabilities, may also be included with the hydroquinone composition. STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN. 1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. [32], Hydroquinone is thought to be the active toxin in Agaricus hondensis mushrooms. In hydroquinone and sodium metabisulfite compositions, it is believed that the sodium metabisulfite oxidizes first and delays the start of any oxidation of the hydroquinone, so that excessive discoloration is delayed or totally avoided. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. This compound is gathered from the beaver's castor sacs.[35]. A preferred embodiment utilizes encapsulation. HVoLg~Z+ wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 77, No. 2017-02-16T10:10:56+01:00 The Density of hydroquinone is . Data 53, 12781282 (2008), A. The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. If youre making your lotion. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. I would like to add retinol and kojic acid to it as well. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. While patients suffer from pigmentation disorders, they may also suffer from other skin disorders and signs of aging, including but not limited to rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. The composition is preferably formulated in separate phases as designated below. Part of Springer Nature. This is a prescription-only ingredient in some countries, including the member states of the European Union under Directives 76/768/EEC:1976. I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. Data 51, 127129 (2006), J. Lim, S. Jang, H. K. Cho, M. S. Shin, H. Kim, J. Chem. Then add it to the ingredients. J. Chem. Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. Remove contact lenses, if present and easy to do. The reservoir opens through a muscle-controlled valve onto a thick-walled reaction chamber. Boucif Belhachemi. Natural antioxidants could replace hydroquinone derivatives used in industry. - 65.21.225.73. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. All information collection is solely used to support ChemPoint customers service communications. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. Treatment with hydroquinone interferes with the action of tyrosinase, which is an enzyme used in the synthesis of melanin, and compositions are sold across the counter at about 2% hydroquinone and by prescription at higher concentrations. The drug is freely soluble in water and in alcohol. Toxicol. Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. The solubility in water is 6.72g/L. Hydroquinone IS a white crystalline substance when pure and is highly soluble in water. n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. 114, 175188 (1996), I. Hahnenkamp, G. Graubner, J. Gmehling, Int. However, a problem with a formulation containing both retinoids and hydroquinone has been their incompatible pH ranges. and our Hydroquinone is combustible when preheated. uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 Rev. This complex dissolves in hot water, where the two molecules dissociate in solution. Hydroquinone is soluble in alcohol solvents such as ethanol and methanol [17]. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. Correspondence to Learn more about Institutional subscriptions, C. M. S. de Mendona, I. P. de Barros Lima, C. F. S. Arago, A. P. B. Gomes, J. Therm. [23] This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. 4. 0 7 r @ &. 0000008435 00000 n [Na+].OC(=O)CC(O)(CC([O-])=O)C(O)=O.OC(=O)CC(O)(CC([O-])=O)C(O)=O, SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS, Preparations for care of the skin for chemically bleaching or whitening the skin, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Acids; Anhydrides, halides or salts thereof, e.g. Retinoids are included in the invention from about 0.01 to about 5%, preferably from about 0.025% to about 2.0%, more preferably from about 0.05% to about 1%, and most preferably from about 0.025% to about 0.5%. The method of item 1 07 wherein the hydroquinone is present in about 4%. 0000053439 00000 n Most preferably, when both a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, are present, the color of the hydroquinone composition is stabilized in the neutral pH range, preferably for greater than about six months, more preferably for greater than about twelve months and most preferably for greater than about eighteen months. SAS Anti-ox booster 1% 0.3g. The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. . Then take the water and put the measurement into the microwave until boiled. Hydroquinone is sold by chemical suppliers. Solubility of Hydroquinone in Different Solvents from - ResearchGate One skilled in the art is familiar with the known protective system technologies, such as encapsulation and entrapment methodologies. 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection.Call a POISON CENTER or doctor/physician if you feel unwell.IF ON SKIN: Gently wash with plenty of soap and water.IF IN EYES: Rinse cautiously with water for several minutes. For more information, please see our InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, Except where otherwise noted, data are given for materials in their. PDF Solubilityof Eastman hydroquinone andderivatives You take the cream, put it in a container, take the powder measurement and add it. Inhalation Remove to fresh air. By clicking Accept, you consent to the use of cookies. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Calorim. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. The aquatic toxicity of hydroquinone to fresh water fish, Daphnia, and algae was between 0.050- . HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. Hydroquinone - Sciencemadness Wiki 0000003430 00000 n Monobenzone: Uses, Interactions, Mechanism of Action - DrugBank [22] The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. 0000008514 00000 n fungichromin, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. Determination and Correlation of Solubilities of Benzoic Acid, Salicylic Acid, Resorcinol and Hydroquinone in Water and in 1-Octanol at Temperatures from 297.25K to 334.45K. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. Hydroquinone compositions are effective but have some undesirable side effects. Reference Tables: SOLUBILITIES - uspbpep.com protecting the retinoids in a protective system; mixing the hydroquinone, and the protected retinoids; and. ~lgM~Gc{1S_1Q/_/v">S 9 Other adverse effects Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150C. It can also be found on eBay and Amazon. Since hydroquinone has a tendency to discolor through oxidation, these antioxidants are used because they have greater tendencies to oxidize than hydroquinone. International Journal of Thermophysics Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Using a laser-monitoring observation technique, the solubility of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid were measured at temperatures ranging from 276.65 K to 345.10 K under the atmospheric pressure. and solubility in water. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . Will glycerol and citric acid react? If yes, under what conditions? ChemPoint will not under any circumstances release personal user information to individuals or companies. Data 51, 16681671 (2006), C. L. Yaws, S.-C. Lin, Enthalpy of fusion at freezing pointOrganic compounds, in Thermophysical Properties of Chemicals and Hydrocarbons, William Andrew Publishing (Elsevier, 2009), pp. Hydrogen peroxide is used and the reaction gives a mixture of hydroquinone and catechol: An accessible route involves the reaction of sodium hydroxide with 1,4-dichlorobenzene. Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. Canon Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications

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